Hidradenitis Suppurativa Genetic Factors

Hormonal Influences on Hidradenitis SuppurativaEnvironmental Triggers of Hidradenitis Suppurativa
hidradenitis suppurativa genetic factors

Familial Cases

Within the Hidradenitis Suppurativa (HS) community, it is not uncommon to hear stories of the condition affecting multiple members of the same family. This observation signals a potential genetic component to HS, suggesting that those with immediate family members suffering from HS may have a heightened risk of developing the condition themselves. At the Hidradenitis Suppurativa Foundation, we recognize the importance of understanding these familial links as they can guide not only diagnosis but also management strategies for individuals and their families.

Genetic Predisposition

The notion that genetics play a role in HS is supported by a growing body of research. This predisposition implies that certain individuals inherit a susceptibility to developing HS, but not HS itself directly. It’s a subtle yet crucial distinction, indicating that while genetics load the gun, environmental factors may pull the trigger. Understanding this predisposition helps in identifying at-risk individuals for early monitoring and intervention.

Inheritance Patterns

Current research has not definitively pinpointed the exact mode of inheritance for HS. However, the presence of HS in multiple family members across generations suggests potential autosomal dominant or polygenic inheritance patterns. These patterns of inheritance are key areas of our ongoing educational efforts to demystify the genetic aspects of HS for patients and families alike.

Candidate Genes

Identifying genes associated with HS is a crucial step towards unraveling the genetic underpinnings of the disease. Several candidate genes, including those involved in inflammatory pathways and hair follicle function, have been the focus of recent studies. Our foundation aims to keep the HS community informed about these findings and their implications for understanding the condition and developing targeted treatments.

Genetic Markers

Alongside specific genes, researchers have also been investigating genetic markers that may be associated with an increased risk of developing HS. These markers, once validated, could potentially be used to predict the onset or severity of HS, allowing for more personalized and effective management strategies for those at risk.

Linkage Studies

Linkage studies involve examining the genetic materials of families affected by HS to identify the inheritance patterns and pinpoint specific genes that may be involved in the condition. These studies are foundational in our understanding of the genetic components of HS and represent an important part of our research advocacy efforts.

HLA Associations

Human Leukocyte Antigen (HLA) associations with HS have been observed, suggesting that the immune system’s genetic makeup may influence susceptibility to HS. These findings underscore the complex interplay between genetics and the immune response in HS, highlighting potential avenues for novel therapeutic interventions.


Polymorphisms, or variations in DNA sequences, have been identified in individuals with HS. These variations could affect how individuals respond to treatments or their likelihood of developing comorbidities, emphasizing the need for genetic research in personalizing HS management.


The heritability of HS, or the proportion of the condition’s variance explained by genetic factors, is an area of active research. Understanding the heritability of HS can inform risk assessments for individuals with a family history of the condition and guide the development of genetic counseling resources.

Gene-Environment Interactions

Lastly, our work acknowledges the significant role of gene-environment interactions in HS. These interactions refer to how environmental factors, such as lifestyle or comorbid conditions, may influence the genetic predisposition for HS. Identifying these interactions is crucial for developing comprehensive management plans that address both genetic and environmental aspects of HS.

At the Hidradenitis Suppurativa Foundation, we are dedicated to advancing research, awareness, and understanding of the genetic factors associated with HS. By collaborating with researchers, clinicians, and the HS community, we strive to pave the way for personalized treatments and improved quality of life for those affected by Hidradenitis Suppurativa. Join us in our mission to unlock the genetic secrets of HS and bring hope to countless individuals and families around the globe.

Hidradenitis Suppurativa Genetic Factors

Additional Resources:

Skin Care Montreal


RGR Pharma

103 Crystal Harbour Drive LaSalle
Ontario N9J 3R6 CA

Providing your patients with quality skin care in Montreal has never been easier; partner with RGR Pharma to offer them the very best. Our proven-effective line of products are formulated to hydrate, heal, protect, rejuvenate, cleanse, and penetrate, revealing healthier looking skin in a shorter timeframe.

Knee Pain Brace Medicare


Do you qualify for a knee pain brace? Medicare recipients can order the MetForce back brace from Affinity Medical Supplies that will provide exceptional support and pain relief. our customer service team is waiting to take your call and assist with size selection and ordering. Let us help you get the most from your plan. Affinitymedicalsupplies.com

Nucalm Newport Beach



3300 Irvine Avenue
Newport Beach CA 92660 US

Relax deeply with NuCalm in Newport Beach at Ascent-Adaptation and Regeneration. Our wellness center, conveniently located in Newport Beach, offers NuCalm therapy to help you achieve deep relaxation and stress relief. Using a unique combination of neuroscience and natural relaxation techniques, NuCalm helps your body and mind enter a state of deep relaxation without the use of drugs or side effects. Experience the ultimate relaxation experience in Newport Beach with NuCalm at Ascent-Adaptation and Regeneration. Recharge, rejuvenate, and restore your well-being. Book your NuCalm session today and discover the transformative power of relaxation.

Polyclonal Antibody Production


Green Mountain Antibodies can take on your polyclonal antibody production and deliver quality results in a short timeframe. Inquire by phone at 802-865-6230 or connect with us through our web form. You'll find a wealth of information on our website that explains our services and our commitment to helping you achieve your goals. Greenmoab.com

IOP Toms River NJ


Overcome Wellness & Recovery, LLC

At our addiction treatment center in Lakewood, NJ, we are dedicated to helping individuals overcome their addictions. We offer a range of services that cater to various needs and situations. One of our most effective programs is the Intensive Outpatient Program (IOP) in Toms River, NJ. This program provides clients with structured therapy sessions while still allowing them to maintain their daily responsibilities.

Alberta TMJ


Sana Dental
(780) 476-3391

Experience pain? Book your emergency dental appointment at Sana Dental in Edmonton, Alberta. We offer Alberta TMJ treatment and a range of dental services for all ages. Conveniently located at 12904 50 Street NW, Suite 202, our clinic provides early morning appointments and free on-site parking. Trust our warm and welcoming team for comprehensive care. Call (780) 476-3391 to schedule now!

SE Calgary Dental


South Calgary Dental & Orthodontics
(587) 352-3100

Contact SE Calgary dental specialists from Legacy Family Dental to schedule a new patient appointment for a checkup, cleaning, second opinion, consultation, or meet & greet. Whatever your smile goals, rest easy knowing that you’re in the right place, where our staff is committed to you and focused on great results.

Why Do I Sleep Better with My Dog


The presence of a pet can make us feel happier and calmer, especially when we’re stressed out. The reason behind this phenomenon is that pets provide unconditional love, which makes people feel loved and cared for. This feeling of security helps them relax and fall asleep faster. Sleepytimestore.com

Sports Injury Rehab Naples FL


Choice Medical Center

1325 S Congress Ave # 106
Boynton Beach FL 33426 US

Sports medicine specialists from Choice Medical Center can offer comprehensive sports injury rehab in Naples, FL. Get the care you need before getting back in the game. If you’re in pain or are not performing to your standards, we can provide diagnostic imaging to see what’s going on inside- then recommend the right treatment plan for healing.

Best Alcohol Detox


Carrara Luxury Drug & Alcohol Rehab

31652 Broad Beach Rd
Malibu CA 90265 US

At Carrara Treatment Center, we understand the critical first step towards recovery is often the best alcohol detox, undertaken with utmost care and precision. Our medically supervised detox program provides a safe and comfortable environment, where individuals battling alcohol dependence can confidently begin their journey to sobriety. With a compassionate approach and evidence-based interventions, we prioritize our clients’ physical and emotional well-being, managing withdrawal symptoms effectively to minimize discomfort. Our professionals are deeply committed to delivering the highest standards of care, ensuring that each client receives a personalized detoxification plan tailored to their unique needs. As advocates for long-term recovery, we not only focus on the detox process but also prepare our clients for the next stages of treatment, solidifying the foundation for a life free from alcohol dependence. Carrara Luxury Drug & Alcohol Rehab

Best Drug Rehab Santa Clarita


Healthy Living Residential Program

(661) 536-5562

What makes Healthy Living the best drug rehab in Santa Clarita? We think it’s a combination of quality treatment and a rare commitment to meeting the individual needs of everyone who walks through our doors. If you need to detox prior to treatment, our medical detox program is one of the best in the world. Call admissions with any questions you have. Healthy Living Residential Program

Winnipeg Chiropractor


RC Walk In Chiro
(204) 942.4476

If you’re in pain, you need to know there’s a Winnipeg chiropractor open for walk-in visits. RC Walk-In Chiropractic believes that by providing patients with a better quality of care, we can more fully meet your needs. If you need x-rays, chiropractic care, massage, or other services, you’ll find our doors open and our staff warmly welcoming.

In Home Care Hillsborough


Agility Health

1710 South Amphlett Boulevard STE 110
San Mateo CA 94402 US
+1 650-453-5100

Looking for top-quality in-home care in Hillsborough? Look no further than Agility Health. Our team of experienced professionals is dedicated to providing the highest level of care for seniors and those in need. Trust us as your go-to provider for in-home care in Hillsborough. Contact Agility Health today to learn more and schedule your services